Figure 5
KEGG pathways enriched during the progression of renal disease in TgUmodC147W identified by clusterProfiler Bioconductor package. The analysed list is composed of genes that are significantly up- or down-regulated in TgUmodC147W female mice at 2 months of age, regardless of their fold change, and that are not differentially expressed at 1 month of age in sex-matched mice. Pathways up-regulated are represented by red bars while the down-regulated are green. The height of bars is proportional to the statistical significance of the term (dotted line corresponds to enrichment P value = 0.05). Fold enrichment of the significant terms is represented as a blue line. Fold enrichment is defined as the ratio gene frequency/background frequency (see Methods for details).
