Figure 8
Inflammatory cell infiltrate in the kidneys of p8 TgUmodC147W mice. (a) Analysis by RT-qPCR of markers of infiltrating cells in TgUmodC147W mice relative to age- and sex-matched TgUmodwt mice (n = 8 TgUmodwt and 6 TgUmodC147W). As in mice at 1 month of age, Cd5 (T cells) and Cd19 (B cells) are barely detectable (data not shown). Inflammatory infiltrating cells in the kidneys of TgUmodC147W mice are essentially represented by macrophages (Cd68). Data are expressed as mean ± s.e.m. **P < 0.01; ***P < 0.001 (unpaired t-test). (b) Representative images of immunofluorescence staining for macrophage marker (F4/80) in kidneys from TgUmodwt and TgUmodC147W mice at p8 (scale bar 50 µm). (c) Quantification of F4/80 positive area. Data are expressed as mean ± s.d. (n = 4 TgUmodwt and 5 TgUmodC147W). **P < 0.01 (unpaired t-test).
