Table 4 List of the top 10 KEGG pathways up- and down-regulated in 1 month-old male Tg^UmodC147W mice relative to age- and sex-matched Tg^Umodwt.

FOCAL ADHESION

0

58/138 (201)

Pik3r1, Ptk2, Prkca, Crk, Col1a2, Ppp1r12a, Itga11, Zyx, Ilk, Tnxb, Igf1, Vwf, Itga10, Itga3, Vav3, Itga9, Egf, Itga5, Vcl, Flnc, Akt3, Shc1, Capn2, Actn4, Itgb6, Vegfc, Tnn, Jun, Col4a2, Pdgfrb, Actb, Ccnd2, Col4a1, Pdgfb, Lamb2, Thbs1, Lamc1, Flna, Itgb4, Cav1, Lamc2, Mylk, Figf, Actn1, Pik3r3, Lama2, Thbs2, Spp1, Col3a1, Col6a3, Col6a2, Col6a1, Pdgfra, Col5a1, Fn1, Col1a1, Tnc, Myl9

ECM RECEPTOR INTERACTION

0

34/57 (84)

Vtn, Col1a2, Cd47, Itga11, Sv2a, Tnxb, Vwf, Itga10, Itga3, Itga9, Agrn, Itga5, Itgb6, Tnn, Col4a2, Cd44, Col4a1, Lamb2, Thbs1, Hspg2, Lamc1, Itgb4, Lamc2, Lama2, Thbs2, Spp1, Col3a1, Col6a3, Col6a2, Col6a1, Col5a1, Fn1, Col1a1, Tnc

RIBOSOME

0.001

37/52 (88)

Rpl39, Rpl23, Rps19, Rpl36a, Rps21, Rpl9, Rpl3, Rpl27a, Rpl19, Rps11, Rpl32, Rplp2, Rps5, Rps2, Rps10, Rpl38, Rpl7a, Rpl22, Rpl28, Rpl35, Rps15a, Rpl30, Rpl37, Rps12, Rps15, Rps8, Rpl18, Rpl18a, Rpl34, Rpl26, Rps6, Rps26, Rps24, Rps9, Rpl31, Rps3, Rps16

DILATED CARDIOMYOPATHY

0.001

22/48 (92)

Prkx, Tgfb3, Itga11, Tgfb1, Igf1, Itga10, Itga3, Itga9, Gnas, Atp2a2, Itga5, Itgb6, Actb, Adcy4, Cacnb3, Adcy6, Itgb4, Slc8a1, Tpm2, Tpm4, Lama2, Tpm1

GAP JUNCTION

0.002

23/51 (90)

Prkca, Nras, Prkx, Csnk1d, Gja1, Gnai2, Tuba1b, Itpr2, Egf, Gnas, Gucy1b3, Prkg1, Pdgfrb, Tubb6, Adcy4, Pdgfb, Adcy6, Itpr3, Htr2b, Gucy1a3, Tuba1a, Pdgfra, Tubb2b

LEUKOCYTE TRANSENDOTHELIAL MIGRATION

0.002

31/73 (118)

Ptpn11, Mapk12, Ctnna1, Pik3r1, Ptk2, Prkca, Icam1, Cxcl12, Rassf5, Cxcr4, Cldn15, Pecam1, Gnai2, Vav3, Plcg2, Msn, Esam, Vcl, Cdh5, Actn4, Actb, Cldn19, Thy1, Actn1, Pik3r3, Cldn16, Cldn4, Vcam1, Cldn10, Mmp2, Myl9

ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC

0.009

24/40 (76)

Itgb1, Dag1, Emd, Itgb5, Cacna2d1, Jup, Ctnna1, Itga11, Gja1, Itga10, Itga3, Itga9, Atp2a2, Itga5, Actn4, Itgb6, Dsp, Actb, Cacnb3, Itgb4, Slc8a1, Actn1, Lama2, Dsg2

HYPERTROPHIC CARDIOMYOPATHY HCM

0.015

18/45 (85)

Tgfb3, Itga11, Tgfb1, Igf1, Itga10, Itga3, Itga9, Atp2a2, Itga5, Itgb6, Actb, Cacnb3, Itgb4, Slc8a1, Tpm2, Tpm4, Lama2, Tpm1

VASCULAR SMOOTH MUSCLE CONTRACTION

0.019

24/63 (115)

Pla2g12a, Prkca, Ppp1r12a, Prkx, Pla2g4b, Itpr2, Gnas, Gucy1b3, Mrvi1, Myh11, Actg2, Ramp2, Prkg1, Ednra, Myl6, Adcy4, Adcy6, Itpr3, Mylk, Avpr1a, Adora2b, Gucy1a3, Myl9, Acta2

CARDIAC MUSCLE CONTRACTION

0.019

20/35 (80)

Cox6c, Cox6b1, Cox7b, Slc9a1, Tpm3, Atp1a2, Cacna2d1, Atp1b3, Cox7a2l, Cyc1, Cox7a1, Atp2a2, Cox6b2, Cacnb3, Atp1b2, Slc8a1, Tpm2, Fxyd2, Tpm4, Tpm1

Down-regulated pathway

FDR

Number of genes

Contributing genes

PEROXISOME

0.001

36/63 (78)

Nudt19, Ephx2, Pecr, Ehhadh, Slc25a17, Acox3, Pipox, Nudt12, Far1, Agps, Cat, Acox1, Mlycd, Prdx5, Ddo, Abcd3, Amacr, Scp2, Dhrs4, Gnpat, Pxmp4, Slc27a2, Sod1, Pex3, Pex16, Gstk1, Pex2, Pex7, Abcd4, Pex14, Hmgcl, Crat, Pex11a, Prdx1, Mpv17, Sod2

BUTANOATE METABOLISM

0.001

11/21 (34)

Acsm3, Aacs, Acat1, Ehhadh, Bdh1, Aldh3a2, Acsm5, Aldh5a1, L2hgdh, Acads, Abat

PROPANOATE METABOLISM

0.015

8/19 (33)

Acat1, Ehhadh, Mlycd, Aldh3a2, Suclg2, Abat, Acss2, Aldh6a1

PYRUVATE METABOLISM

0.019

10/26 (40)

Ldhd, Acot12, Acat1, Pck1, Aldh3a2, Acss2, Mdh1, Grhpr, Pklr, Dld

GLYCINE SERINE AND THREONINE METABOLISM

0.019

11/24 (31)

Cbs, Pipox, Shmt2, Gnmt, Sardh, Srr, Chdh, Dmgdh, Glyctk, Agxt2, Gamt

CYSTEINE AND METHIONINE METABOLISM

0.020

8/19 (34)

Cbs, Ahcy, Mat2a, Mpst, Ahcyl1, Mtr, Trdmt1, Mat2b

SELENOAMINO_ACID_METABOLISM

0.020

9/21 (26)

Cbs, Ahcy, Ggt1, Mat2a, Ahcyl1, Papss1, Mat2b, Mars2, Sephs2

TRYPTOPHAN METABOLISM

0.065

9/23 (40)

Inmt, Acat1, Haao, Ehhadh, Afmid, Cat, Aldh3a2, Gcdh, Kmo

LYSINE DEGRADATION

0.069

8/34 (64)

Acat1, Aass, Ehhadh, Pipox, Plod2, Aldh3a2, Plod3, Gcdh

SYSTEMIC LUPUS ERYTHEMATOSUS

0.071

19/56 (140)

C8a, C8g, Hist1h4h, Hist1h4i, Hist1h4a, Hist1h4f, Hist1h4j, Hist1h2be, Hist1h2bn, Hist1h2bk, Hist1h4k, Hist1h2bj, Hist1h2bm, Hist1h2bc, Hist1h2bh, Fcgr2b, Hist1h2bf, C4b, C4a