Figure 4 | Scientific Reports

Figure 4

From: Proteomics/phosphoproteomics of left ventricular biopsies from patients with surgical coronary revascularization and pigs with coronary occlusion/reperfusion: remote ischemic preconditioning

Figure 4

Vulcano plots of all detected proteins in the phosphoproteome/proteome analysis in human left ventricular biopsies. Vulcano plots of −Log(10)p-value over -fold higher phosphorylation/expression between groups (remote ischemic preconditioning (RIPC)/sham) of all proteins detected after (a) phosphopeptide enrichment, (b) in-gel digestion, (c) in-solution digestion of Tris/sodium dodecyl sulfate (Tris/SDS) and (d) radioimmunoprecipitation assay (RIPA) buffer-lysed human left ventricular biopsies taken at early reperfusion. A −Log(10)p-value of ≥1.3 corresponds to a p-value of ≤0.05. The false discovery rate (FDR) significance cut-off curve indicates only a significant increase of prostaglandin reductase 2 with RIPC than with sham in human biopsies lysed in RIPA buffer. Grey squares: phosphopeptides/proteins without FDR-based statistical difference between RIPC and sham. Black square: protein with FDR-based statistical difference between RIPC and sham.

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