Table 2 PT-INR, APTT, and T-TAS parameters according to the type of anticoagulant.
From: Direct Oral Anticoagulants Form Thrombus Different From Warfarin in a Microchip Flow Chamber System
Warfarin (n = 29) | Dabigatran (n = 19) | Rivaroxaban (n = 47) | Apixaban (n = 25) | P value | |
|---|---|---|---|---|---|
PT-INR | |||||
Off-anticoagulants | 1.06 [1.03–1.12] | 1.03 [1.00–1.09] | 1.06 [1.01–1.10] | 1.05 [1.01–1.09] | 0.532 |
On-anticoagulants | 1.91 [1.60–2.20] | 1.10 [1.05–1.14] | 1.11 [1.05–1.18] | 1.16 [1.10–1.23] | <0.001 |
APTT (sec) | |||||
Off-anticoagulants | 31.1 [29.7–34.0] | 34.5 [32.1–38.3] | 29.9 [28.5–32.9] | 31.9 [29.9–34.3] | 0.002 |
On-anticoagulants | 38.6 [36.0–44.4] | 42.7 [37.9–47.2] | 33.4 [31.4–36.5] | 33.8 [31.8–36.8] | <0.001 |
AR10-AUC30 | |||||
Off-anticoagulants | 1749 [1646–1824] | 1786 [1691–1861] | 1812 [1686–1861] | 1781 [1673–1861] | 0.460 |
On-anticoagulants | 1623 [1385–1706] | 1601 [1456–1708] | 1657 [1590–1742] | 1630 [1469–1771] | 0.263 |
Thrombi area (%) | |||||
3 minutes | |||||
Off-anticoagulants | 9.6 [8.2–12.4] | 9.2 [7.2–12.0] | 10.4 [8.5–12.9] | 10.1 [9.0–11.5] | 0.351 |
On-anticoagulants | 6.8 [3.3–8.4] | 5.6 [4.3–8.4] | 8.1 [6.7–11.0] | 9.4 [6.2–10.6] | <0.001 |
6 minutes | |||||
Off-anticoagulants | 14.5 [11.2–19.4] | 15.5 [11.2–19.2] | 17.5 [13.6–20.4] | 15.3 [13.5–18.1] | 0.574 |
On-anticoagulants | 9.9 [6.5–13.4] | 10.0 [7.3–13.4] | 13.6 [10.9–17.0] | 13.9 [11.3–18.0] | <0.001 |
9 minutes | |||||
Off-anticoagulants | 18.7 [15.1–22.7] | 23.4 [19.2–27.9] | 21.5 [14.3–27.4] | 22.0 [18.2–23.9] | 0.373 |
On-anticoagulants | 17.2 [9.4–22.2] | 17.8 [13.3–21.4] | 18.7 [15.5–24.6] | 20.8 [15.3–24.1] | 0.077 |
