Figure 1
From: Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety
Associations of the PER3 single nucleotide polymorphism (SNP rs228697) with circadian chronotype and anxiety. (A) Frequencies of C and G alleles in morning-type (n = 48), intermediates (n = 159), and evening-type (n = 103) self-reported chronotypes. The frequency of the C allele is lower in evening-types (OR = 17.86, 95% CI = 0.99–321.61, p = 0.05). (B) Frequencies of the PER3 SNP genotypes in each chronotype (χ2 = 29.20, n = 1, p < 0.001). Individuals homozygous for the G-allele are more likely to be evening-types. (C) Average self-reported MEQ scores (±SD) are lower in GG homozygotes compared to other genotypes (t = 7.415, df = 308, p = 0.016). (D) Average trait anxiety scores (±SD) are higher in GG homozygous individuals (F(2,305) = 3.195, p = 0.042).
