Figure 4
From: Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety
Time series data reflecting SNP/VNTR conditions for a representative individual. (A) The model accurately reflects predicted phenotypes for individuals with PER3-P415A/H417R mutations, displaying a shorter period for nuclear BMAL1 mRNA after an 80% reduction in PER1-PER3 binding rate and an 8-fold increase in PER3 degradation rate (p < 0.001)30. (See Tables S2, S5, and S6 for more information about variants). (B) The model accurately reflects predicted phenotypes for individuals with PER3-P864A missense mutations, displaying a lengthened period for a representative individual after an 80% decrease in PER3-CKI binding (p < 0.001)11. (C) The model accurately represents individuals representative of homozygotes of PER3 4,4 after a 40% decrease in PER3 phosphorylation rate25. The PER3 4,4 homozygous individual displays a lengthened BMAL1 mRNA period relative to a heterozygous individual (p < 0.001). (D) The model accurately represents individuals representative of homozygotes of PER3 5,5  25. The PER3 5,5 homozygous individual displays a shortened BMAL1 mRNA period relative to a heterozygous individual after a 4-fold increase in PER3 phosphorylation rate (p < 0.001)25.
