Figure 1 | Scientific Reports

Figure 1

From: High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature

Figure 1

High fat diet promotes weight gain, hyperglycemia, hyperinsulemia and changes to body composition. (A) Schematic diagram showing diet regimes of high fat diet- (HFD), lean diet- (LD) and normal chow-fed mice, and the longitudinal timing for analysis of age related and surgically-induced OA. (B) Nine-week old C57BL/6J mice were placed on high fat diet or lean diet until 18 weeks (6 months of age) at which time the mice were returned to a normal chow diet up to 12 months of age. Body weight, fasting blood glucose, insulin levels, body area, bone mineral density (BMD), bone mineral content (BMC) and body fat percent were determined longitudinally. All results are expressed as mean ± SD. Data were analyzed by Two-way ANOVA followed by Holm-Sidak multiple comparison tests. *p < 0.05 (LD vs HFD at each time point); n = 10.

Back to article page