Figure 2 | Scientific Reports

Figure 2

From: High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature

Figure 2

High fat diet-fed mice exhibit accelerated surgically-induced OA. (A) Representative histological images of Safranin-O/Fast Green stained knee joint sections from lean diet (LD) and high fat diet (HFD)-fed mice that underwent destabilisation of medial meniscus (DMM surgery) at 18 weeks of diet (6 months of age) and were collected at 10 or 20-weeks post-surgery. Magnification is 10x and 20x. (B) Severity of OA pathogenesis was determined by OARSI histopathology grading of mouse femoral condyles and tibial plateaus, and number of chondrocytes per area were counted. Data were analysed by Two-way ANOVA followed by Holm-Sidak multiple comparison tests. Data are expressed as mean ± SD (n = 10). +p < 0.05, LD vs HFD at 10-weeks or LD vs HFD 20-weeks post-surgery. *p < 0.05, HFD at 10-weeks vs HFD at 20-weeks of post-surgery or LD at 10 weeks vs LD 20 weeks of post-surgery.

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