Figure 4 | Scientific Reports

Figure 4

From: High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature

Figure 4

High fat diet-fed mice exhibit distinct and sustained longitudinal changes in selected metabolites. Metabolites shown were selected based on VIP scores ≥1 and One-way ANOVA (p < 0.05). (A) Heat maps showing the median-normalized fold change in the metabolites levels of mice at baseline, and 18 weeks of high fat diet (HFD) or lean diet (LD), or at baseline and 9 months of age from HFD- and LD- fed mice. (B) Venn diagrams representing metabolites identified and grouped based on One-Way ANOVA and Fisher's LSD post-hoc tests (p < 0.05 representing a significant difference between individual groups). Metabolites not meeting predetermined cut-offs are located centrally in the 18 week and 9 month venn diagrams (126 and 140 metabolites, respectively) (n = 10 per group per time point).

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