Table 1 ROC analysis of metabolites longitudinally upregulated in HFD-induced osteoarthritis.

From: High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature

Metabolite

AUC

95% CI

Fold change (HFD relative to LD)

T-test

lysoPCaC17:0

0.96429

0.786–1

1.40

0.0035

lysoPCaC20:4

0.92857

0.714–1

1.60

0.0063

PCaaC36:2

0.92857

0.714–1

1.20

0.0176

lysoPCaC18:0

0.85714

0.571–1

1.28

0.0419

  1. Table of selected metabolites identified from VIP ≥ 1 and significantly upregulated by One-way ANOVA (p < 0.05) at 18 weeks of diet and 9 months of age in HFD-fed mouse plasma vs LD-fed or baseline mouse plasma. AUC; area under curve, CI; confidence interval; HFD; high fat diet; LD; Lean diet. Significant P-values (p < 0.05) determined by Student’s t-test of log-transformed, auto-scaled data comparing animals with severe (OARSI score ≥ 3) vs. non-severe (OARSI score <3) osteoarthritis.
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