Table 1 Summary of the effect of probiotics on the longevity of C. elegans.
Strain | Mechanism | References | |
|---|---|---|---|
Lactobacillus gasseri SBT2055 | Increased median survival by 37%; higher pharyngeal pumping; enhanced resistance against intrinsic oxidative stress | Activated NSY-1–SEK-1–PMK-1; up-regulated the expression of SKN-1 and its target genes | |
Weissella koreensis KACC 11853 Weissella cibaria KACC 11845 | Increased longevity; reduced pharyngeal pumping | Activated JNK-1–DAF-16 related to the stress response; Activated AAK-2–DAF-16 related to dietary restriction | |
Lactobacillus salivarius FDB89 | Extended the mean life span by 11.9%; reduced reproductive capacity, pharyngeal pumping rate and growth; increased SOD and XTT reduction activity | Dietary restriction dependent (eat-2 and food gradient feeding assay) | |
Bifidobacterium infantis ATCC15697 | Increased longevity in a dose-dependent manner; enhanced resistance to oxidative and heat stress | Activated PMK-1–SKN-1 to regulate phase 2 detoxification; DAF-2 is involved in SKN-1 regulation; the bacterial cell wall is a major effective constituent | |
Lactobacillus rhamnosus CNCM I-3690 | Increased median survival by 3 days (from 15 days to 18 days); enhanced resistance to oxidative stress | Dependent (at least partially) on the DAF-2/DAF-16 signaling pathway; SKN-1 also involved | |
