Figure 1
From: Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood
PCMS but not CRS nor CUS during adolescence facilitated the extinction and prevented fear memory return in adulthood. (a,d) Experimental timeline. (b) PCMS, CRS or CUS during adolescence had no significant effect on the conditioning of contextual fear memory (n = 8–10 per group). (c) PCMS, CRS nor CUS during adolescence had no significant effect on the short term and long term fear memory (n = 8–10 per group). (e) PCMS exposure during adolescence reduced fear responses in the extinction test and reinstatement test in adulthood (n = 8–10 per group). (f) PCMS exposure during adolescence reduced fear responses in the extinction test and spontaneous recovery test in adulthood (n = 8–10 per group). The data are expressed as the mean ± SEM. *p < 0.05, compared with the control group. PCMS, predictable chronic mild stress; CRS, chronic restraint stress; CUS, chronic unpredictable stress.
