Figure 1

DM aggravates blood–spinal cord barrier (BSCB) permeability after SCI. After SCI, barrier permeability was measured 1d after injury, using Evans Blue (EB) dye in sham, SCI, and SCI + DM group. (A,B) Representative whole spinal cords and quantification of BSCB permeability data in each group showing EB dye permeabilized into the spinal cord, n = 4. (C,D) Representative confocal images of EB extravasation and quantification of the fluorescence intensity of EB in each group. Scale bar = 1 mm. n = 4, *p < 0.05, **p < 0.01 vs sham group, #p < 0.05, ##p < 0.01 vs SCI group.