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Figure 1

From: A multi-parametric analysis of Trypanosoma cruzi infection: common pathophysiologic patterns beyond extreme heterogeneity of host responses

Figure 1

Trypanosoma cruzi strains differently impact organs during acute and chronic infection. (A) Damage to intestine and heart vary among strains and phases. Damage was assessed upon dissection by macroscopic observation and resistance to pressure and extension, resulting in a 3-grade scale: 0, unaffected (white), 1, low damage (gray), 2, high damage (black). Each animal is represented by a coloured square. Hepatosplenomegaly is a common feature of both acute and chronic phases, with sensible differences among strains. (B,C) Mass index is the weight of infected animals normalized to controls, grouped per strain and per phase (coloured bars), and according to organ damage (white, gray, and black bars) for liver (B) and spleen (C). Dotted lines stand for the mean of all infected animals. Data are the mean per group ± S.E.M.

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