Table 1 Phenotype assignment according to CYP2D6 and CYP2C19 genotype.

From: CYP2C19*2 and CYP2C19*17 variants and effect of tamoxifen on breast cancer recurrence: Analysis of the International Tamoxifen Pharmacogenomics Consortium dataset

Inferred phenotype levels of combined CYP2D6 phenotypes1 and CYP2C19*17 genotypes

Level

CYP2D6 phenotype

CYP2C19*17 allele presence

1

EM/EM

Yes

2

EM/EM

No

EM/IM

Yes

EM/PM

Yes

3

EM/IM

No

EM/PM

No

IM/PM

Yes or No

IM/IM

Yes or No

PM/PM

Yes or No

Inferred phenotype levels of combined CYP2D6 phenotypes1 and CYP2C19*2 genotypes

Level

CYP2D6 phenotype

CYP2C19*2 allele presence

1

EM/EM

No

2

EM/EM

Yes

EM/IM

No

EM/PM

No

3

EM/IM

Yes

EM/PM

Yes

IM/PM

Yes or No

IM/IM

Yes or No

PM/PM

Yes or No

  1. 1CYP2D6 UM considered as EM for creation of these levels.