Table 4 Cox proportional hazard ratios for combinations of CYP2D6 metabolizer phenotypes with CYP2C19*2 or CYP2C19*17 genotypes and Disease Free Survival.

From: CYP2C19*2 and CYP2C19*17 variants and effect of tamoxifen on breast cancer recurrence: Analysis of the International Tamoxifen Pharmacogenomics Consortium dataset

Comparison

Hazard Ratio (95% CI); (N)

CYP2C19*2

Level1 3

1.0 (Reference); (85)

Level 2

0.89 (0.46–1.74); (539)

Level 1

0.86 (0.45–1.66); (836)

CYP2C19*17

Level 3

1.0 (Reference); (230)

Level 2

1.21 (0.80–1.85); (1158)

Level 1

1.19 (0.73–1.94); (376)

  1. 1Levels are defined in Table 1.
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