Table 4 Serum chemokines, cytokines, and growth/stimulating factors.

From: Immune dysregulation in patients with carpal tunnel syndrome

Marker

Controls

CTS

P-value

Chemokines

CCL4 (MIP-1β)

2.79 (1.60–4.67)

5.03 (3.74–7.49)

0.0369

CCL5 (RANTES)

28.89 (25.57–40.38)

49.28 (44.87–56.25)

0.000035*

Eotaxin

11.46 (5.49–20.76)

20.07 (11.61–25.70)

0.1011

CXCL10 (IP-10)

20.53 (13.84–28.54)

37.76 (31.2–43.11)

0.0010*

CCL2 (MCP-1)

7.83 (1.4–14.2)

14.78 (11.5–20.26)

0.0100

CXCL8 (IL-8)

5.33 (4.12–8.91)

11.37 (7.95–19.72)

0.0009*

Cytokines

IL-6

1.42 (1.16–1.85)

1.7 (1.37–2.23)

0.080

IFNγ

15.2 (11.15–19.37)

19.84 (12.04–24.07)

0.113

IL-1RA

33.79 (24.69–49.32)

37.89 (28.7–49.32)

1.000

IL-5

1.07 (0–1.63)

1.53 (1.16–2)

0.179

TNFα

0 (0–3.33)

2.89 (0–3.79)

0.066

IL-2

0 (0–0)

0 (0–0)

0.788

IL-13

0 (0–0)

0 (0–0)

0.782

IL-4

0.58 (0.45–0.72)

0.71 (0.63–0.84)

0.025

IL-10

1.82 (1.49–3.22)

2.91 (1.62–3.86)

0.372

IL-7

0 (0–1.57)

1.64 (0–2.21)

0.095

IL-12

1.4 (1.03–1.79)

2.11 (1.59–3.12)

0.013

IL-17A

0 (0–1.03)

1.89 (0–2.93)

0.005

IL-9

1.15 (0.76–1.56)

2.11 (1.56–4.03)

0.005

Growth/Stimulating factors

VEGF

1.41 (0–2.03)

5.94 (3.19–7.49)

0.00025*

PDGF

22.18 (14.34–41.14)

56.60 (35.11–87.77)

0.00383

G-CSF

13.31 (9.95–19.41)

18.09 (14.16–21.19)

0.05107

  1. Data are presented as median (pg/ml) and 95% confidence interval. P-values calculated using Mann–Whitney U test. *Denotes significance following Bonferroni correction for multiple comparisons (P < 0.0023).