Figure 4

Connectivity fluctuations. Six representative deep nuclear and cerebellar regions which revealed an increased dynamic functional connectivity (DLC) during sedation is presented. The strength of the Z correlation on the Y-axis is plotted across the sliding window time points from 1 to 59 on the X-axis. The DLC during baseline awake state is depicted in green and during the sedated state is shown in red. The bar graph in the inset reveals the standard deviations (SD) in the Z correlation strengths during the two conditions. Significant sedation-induced increased connectivity involving the thalamus, basal ganglia and cerebellum with an increased SD demonstrating a “pulsatile” pattern with intermittent periods touching the zero line is most prominent in the cerebellum, basal ganglia and insula.