Figure 3 | Scientific Reports

Figure 3

From: The Candida albicans HIR histone chaperone regulates the yeast-to-hyphae transition by controlling the sensitivity to morphogenesis signals

Figure 3

Hir1 affects the transcriptional amplitude during initiation of hyphal formation. (A) Absolute numbers of differentially expressed transcripts between WT and the hir1Δ/Δ mutant during yeast (y) or hyphal (h) growth. Differentially expressed genes were defined by FDR < 0.05. FC, fold change. (B) The transcriptional profile of hir1Δ/Δ cells showed high similarity to WT cells. log2-fold changes in RNA expression in WT cells during the yeast-to-hyphae transition (x-axis) were plotted against the log2-fold change in mRNA levels in hir1Δ/Δ cells during the yeast-to-hyphae transition (y-axis). (C) Loss of HIR1 causes transcriptional deregulation during hyphal initiation. Each dot corresponds to one ORF. The log2-fold changes in RNA expression in WT cells during the yeast-to-hyphae transition (x-axis) were plotted against the log2-fold changes between HIR1 mutant and WT cells in response to hyphal-inducing conditions (y-axis). (B,C) Significantly differentially expressed genes in the hir1Δ/Δ knock-out versus WT are depicted in green and were defined by an at least 1.5-fold change and FDR < 0.05.

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