Figure 2 | Scientific Reports

Figure 2

From: Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers

Figure 2

Immunization schedule of dromedaries with subtype C SOSIPs. Animals 54A and 6A5 received optC SOSIP, whereas DBO and O5E received a mixture of ZM197M and CAP45 SOSIPs. The first immunization cycle consisted of 7 weekly protein boosts followed by an additional boost seven months later. Red arrows indicate the timepoints of serum samples used for neutralization assays. Blood samples from timepoints t1 and t2 were also used for the generation of phage displayed nanobody libraries for all 4 animals.

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