Figure 7
Schematic presentation of the functional properties of FPC. FPC exerts its effects on the cytoskeleton and cell-cell junctions by indirectly regulating the activity of RhoA via the E3 family of ligases. FPC helps maintain balanced TGF-β signaling by regulating the targeting of SMURF1 and 2 to TGF-β receptors after ligand binding. FPC indirectly affects sodium balance by regulating the activity of NEDD4-2 in the CD and thereby affecting degradation of ENaC. These all functions are conducted through NDFIP2 in FPC positive vesicle.
