Figure 3
Average nicotine intake during the last three IVSA sessions. The number of nicotine infusions was highly correlated when two different doses were tested (a). The gray area represents the 95% confidence interval of the linear model. When compared to the 30 μg/kg/inf dose, the number of infusions almost doubled across the strains when 15 μg/kg/inf was used. As a result, the amount of nicotine obtained was very similar between the two doses (b). Three-way repeated measures ANOVA found there was a significant effect of strain on nicotine intake (F11,160 = 9.0, p < 0.001) but dose (F1,166 = 0.13, p > 0.05) and session (F2,320 = 0.17, p > 0.05) had no effect.
