Table 4 Effect of nicotine on the acquisition of socially acquired nicotine IVSA, CFA, and extinction of CFA.

Strain	n1, n2	Acquisition of IVSA						CFA test		Extinction of CFA
		Active Licks			Infusions			Active Licks	Rewards	Active Licks	Rewards
		Df	F	p	Df	F	p	p	p	p	p
BN	(4,3)	(1,5)	309.5	<0.001	(1,5)	158.7	<0.001	<0.05	<0.05	>0.05	>0.05
DA	(7,4)	(1,9)	60.4	<0.001	(1,9)	127.3	<0.001	<0.05	<0.05	>0.05	>0.05
F344	(6,4)	(1,8)	58.7	<0.001	(1,8)	13.5	<0.01	<0.01	<0.05	<0.01	<0.05
LEW	(7,5)	(1,10)	160.0	<0.001	(1,10)	26.9	<0.001	<0.001	<0.05	<0.01	>0.05
SHR	(7,4)	(1,9)	8.1	<0.05	(1,7)	7.8	<0.05	>0.05	>0.05	<0.05	<0.05
WKY	(6,5)	(1,9)	211.6	<0.001	(1,9)	14.8	<0.01	<0.001	<0.05	<0.05	<0.01
FD	(7,5)	(1,10)	12.3	<0.01	(1,10)	9.5	<0.05	<0.01	<0.05	<0.05	<0.05
FL	(7,5)	(1,10)	128.8	<0.001	(1,10)	14.5	<0.01	<0.001	<0.05	<0.01	<0.01
FS	(5,4)	(1,7)	113.9	<0.001	(1,7)	8.5	<0.05	<0.05	<0.05	>0.05	>0.05
LB	(4,4)	(1,6)	63.2	<0.001	(1,6)	13.4	<0.05	<0.001	<0.05	>0.05	>0.05
LS	(6,5)	(1,9)	44.3	<0.001	(1,9)	14.0	<0.01	>0.05	>0.05	>0.05	>0.05
WL	(6,6)	(1,10)	110.1	<0.001	(1,10)	17.4	<0.01	<0.01	<0.05	>0.05	>0.05

Two groups of rats received i.v saline or nicotine with contingent flavor cue in the abscence of demonstrator rats for each strain. n1 and n2 are the number of animals used for the nicotine and saline groups, respectively. The number of licks on the active spout and infusions were compared between the two treatment groups (i.e., nicotine vs saline) for each strain using two-way repeated measures ANOVA. These rats then were tested for CFA during the fourth session (i.e. CFA test). CFA tests continued for a total of five daily sessions and the data on the last session were used to evaluate the extinction of CFA. Two-tailed independ t-tests were used to compare the effect of treatment on CFA and extinction of CFA.

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