Table 1 Patient data from 7 pet dogs with spontaneous, chronic infections with MDR bacteria treated with activated MSC.

From: Activated Mesenchymal Stem Cells Interact with Antibiotics and Host Innate Immune Responses to Control Chronic Bacterial Infections

Dog

Infection site

Infection duration

Organism(s)

Bacteriologic response (8 wks)

Clinical Response (8 wks

1

Post-operative stifle infection

12 months

MRSP

Eliminated

Resolved

2

Post-operative stifle infection

6 mos

MRSP

Eliminated

Resolved

3

Draining tract stifle

4 mos

MRSP

Eliminated

Resolved

4

Soft tissue injury- paw

4 weeks

PA, EC

Eliminated

Resolved

5

Infected bone plate

3 mos

MRSP, EC, Crny, Kleb

Eliminated (except MRSP)

Improved

6

Cervical abscess from pacemaker lead

24 mos

MRSP- 2 strains

Unchanged

Improved

7

Deep pyoderma - paws

9 mos

MRSP

Eliminated

Resolved

  1. PA = Pseudomonas aeruginosa, EC = Eschericia coli, MRSP = methcillin resistant Staphylococcus pseudointermedius, Crny = Corynebacterium sp, Kleb = Klebsiella sp.