Table 2 Associations between p-mTOR expression and clinicopathologic parameters in 160 patients with tongue squamous cell carcinoma.

Parameters		p-mTOR expression
Parameters		Low	Over	P value
Age	≤52 y/o	42	40	0.26
Age	>52 y/o	33	45
Pathological T classification	T1/2	44	54	0.53
Pathological T classification	T3/4	31	31
Pathological N classification	N0	40	47	0.80
Pathological N classification	N1/2/3	35	38
Pathological 7^th AJCC Stage	I/II	26	39	0.15
Pathological 7^th AJCC Stage	III/IV	49	46
Depth of invasion (mm)	<4 mm	8	12	0.51
Depth of invasion (mm)	≥4 mm	67	73
Histologic grade	1	42	51	0.61
Histologic grade	2/3	33	34
Vascular invasion	Absent	66	66	0.085
Vascular invasion	Present	9	19
Perineural invasion	Absent	38	51	0.24
Perineural invasion	Present	37	34
Extracapsular spread	Absent	56	64	0.93
Extracapsular spread	Present	19	21
Margin status	Negative	70	78	0.71
Margin status	Positive/close	5	7
Smoking	Absent	14	15	0.87
Smoking	Present	61	70
Alcohol	Absent	13	19	0.43
Alcohol	Present	62	66
Betel-nut chewing	Absent	20	19	0.53
Betel-nut chewing	Present	55	66

Abbreviation: p-mTOR, phosphorylated mammalian target of rapamycin. *Statistically significant. х² test or Fisher’s exact test was used for statistically analyzed.

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