Figure 4 | Scientific Reports

Figure 4

From: Prenatal hypoxia leads to hypertension, renal renin-angiotensin system activation and exacerbates salt-induced pathology in a sex-specific manner

Figure 4

Renal histopathology of offspring at 12 months of age. Estimated glomerular number, interstitial fibrosis expressed as a percentage of renal tissue, and relative mRNA expression of Tgfb1 and Kim-1 in male (A) and female (B) offspring. (C) Period acid Schiff’s staining of the renal cortex containing glomeruli (scale bar represents 50 µm) and Masson’s Trichrome staining of renal fibrosis (blue) in male offspring (scale bar represents 100 µm). Glomerular number was analysed using a Student’s t test (**P = 0.007). Interstitial fibrosis and mRNA expression analysed via two-way ANOVA. Values are mean ± SEM. Male: N = 5–11/group; female: N = 6–8/group. Control: open bars; hypoxia: closed bars.

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