Table 3 Independent Predictors of Longitudinal Changes in eGFR.

From: Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease

Predictors*

Effect estimate (% change in eGFR) (95% CI)

P-value

Low sCD40L & High sCD40R

3.21 (0.59, 5.83)

0.016

Baseline MDRD eGFR

1.01 (0.94, 1.0)

<0.001

Year (out from baseline)

−1.32 (−1.80, −0.85)

<0.001

PVD

1.92 (0.16, 3.67)

0.03

  1. Only statistically significant predictors of longitudinal changes in eGFR (baseline out to 4 years) are included. The model was adjusted for, age, sex, baseline eGFR, systolic blood pressure (SBP), history of peripheral vascular disease (PVD) and diabetes mellitus, primary renal disease, and baseline ACEi/ARB or aspirin use.
  2. *Using High sCD40L & Low sCD40R as the reference group
  3. Abbreviations: MDRD, Modified Diet in Renal Disease study; GFR, estimated glomerular filtration rate; sCD40L, soluble CD40 ligand; sCD40R, soluble CD40 receptor; BP, blood pressure; and CI, confidence interval; and PVD, peripheral vascular disease.
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