Figure 7 | Scientific Reports

Figure 7

From: Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling

Figure 7

Schematic representation of the glycerophospholipid and sphingolipid pathways in human melanoma cells. Box plots show relative changes in lipid species with VIP > 1.0 in melanocytes and melanoma cells with different metastatic potential (HEMn-LP, A375, A2058) as determined by direct infusion-mass spectrometry. ANOVA, followed by Tukey’s post-hoc test (p < 0.05), was conducted, and different letters indicate statistically significant differences between samples. Proposed pathways were based on data in the KEGG database (http://www.genome.jp/kegg/). PC, phosphatidylcholine; PE, phosphatidylethanolamine; PG, phosphatidylglycerol; PI, phosphatidylinositol; PS, phosphatidylserine; LPA, lysophosphatidic acid; PA, phosphatidic acid; DAG, diacylglycerol; CDP-DAG, cytidine diphosphate-diacylglycerol; Pm-CoA, palmitoyl coenzyme A; S1P, sphingosine-1-phosphate.

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