Figure 1

An overview of the present literature understanding of the phase behaviour of Monoolein when doped with increasing molar proportions of (a) DOPE and (b) DOPG. (a) demonstrates that upon addition of zwitterionic DOPE, Cherezov et al.¹⁹ found a slight decrease in the \({{\rm{Q}}}_{II}^{D}\) phase lattice parameter, before the system took on the inverse hexagonal phase at above 20 mol%, a similar finding to phase work (with no lattice parameter information) done by Templer et al.²⁰. (b) Shows that the work of Tyler et al.²¹ and Awad et al.²⁵ finds an initial phase change from \({{\rm{Q}}}_{II}^{D}\) to \({{\rm{Q}}}_{II}^{P}\) upon addition of the anionic lipid DOPG, a subsequent swelling of the \({{\rm{Q}}}_{II}^{P}\) phase, before a further phase change to the L _α . We note, however, that Tyler et al. undertook their experiments at temperatures too high for practical application purposes, and that Awad et al. undertook their measurements in a 10 mM PIPES buffer.