Table 1 Baseline demographics and gastrointestinal hormone levels in morbidly obese patients (Group 1) pre- and 3 months post-LSG after liquid test meal (408 kcal) stimulation.

From: Deregulation of transcription factors controlling intestinal epithelial cell differentiation; a predisposing factor for reduced enteroendocrine cell number in morbidly obese individuals

Parameter

Preoperative (n = 14)

3 months (n = 14)

P value

Gender: male/female

4/10

—

—

Age (years)

37 ± 3

—

—

BMI (kg/m 2 )

45.5 ± 1.7

39.3 ± 1.4

p ≤ 0.001

Insulin

Fasting insulin (µU/ml)

36.3 ± 6.5

25.0 ± 3.8

p = 0.036

AUC 0–180 min.

15,371.5 ± 3,799.0

10,954.3 ± 1,534.4

p = 0.297

Cmax (µU/ml)

152.3 ± 22.7

182.1 ± 24.9

p = 0.361

Glucose

Fasting glucose (mmol/l)

6.3 ± 0.5

5.3 ± 0.2

p = 0.008

AUC 0–180 min.

1,070.3 ± 64.0

966.7 ± 36.0

p = 0.040

Cmax (mmol/l)

7.8 ± 0.8

7.4 ± 0.5

p = 0.493

HOMA Index

11.2 ± 2.8

6.3 ± 1.3

p = 0.019

Ghrelin

Fasting ghrelin (pg/ml)

504.9 ± 59.6

272.4 ± 13.9

p = 0.001

AUC 0–180 min.

89,822.5 ± 9,034.7

50,690.5 ± 2,961.4

p = 0.001

Cmax (pg/ml)

535.6 ± 56.2

308.2 ± 17.5

p = 0.001

CCK

Fasting CCK (pMol/ml)

1.0 ± 0.1

0.8 ± 0.0

p = 0.231

AUC 0–180 min.

573.3 ± 73.8

777.1 ± 128.3

p = 0.015

Cmax (pMol/ml)

4.6 ± 0.6

13.6 ± 1.2

p < 0.001

GLP-1

Fasting GLP-1 (pg/ml)

1.5 ± 0.4

1.1 ± 0.1

p = 0.243

AUC 0–180 min.

354.8 ± 62.4

959.4 ± 136.0

p = 0.004

Cmax (pg/ml)

2.6 ± 0.4

13.4 ± 1.9

p < 0.001

PYY

Fasting PYY (pg/ml)

113.6 ± 6.9

95.6 ± 8.6

p = 0.059

AUC 0–180 min.

23,141.9 ± 1,212.2

43,329.4 ± 7,206.8

p = 0.022

Cmax (pg/ml)

150.5 ± 7.7

326.8 ± 62.6

p = 0.019

  1. Data represent means ± SEM; AUC = area under the concentration time profile; Cmax = maximum plasma concentrations. p-value: pre versus post-surgery, using a Student’s paired t-test.
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