Figure 2
Two dimensional free energy landscape of hIAPP dimer in the membrane environments as the functions of order parameters β-score8–16 and β-score27–35. The representative structure of free energy minimum on the profile are given, the central region from residue 20 to 29 was colored by red and the disulfide bonds between residues 2 and 7 on each chain were represent in stick model. The yellow dashed line described the dominant free energy pathway from the disordered state to the folded fibril state. The free energy of the minima corresponding to minimum 1 were labeled in the unit of kJ/mol.
