Figure 7 | Scientific Reports

Figure 7

From: Characterization of the Mollusc RIG-I/MAVS Pathway Reveals an Archaic Antiviral Signalling Framework in Invertebrates

Figure 7

CgIRF2 and CgIRF8 respond to poly(I:C) challenge and activate human IFNβ and ISRE promoters. (A) Expression profile of CgIRF2 mRNA after poly(I:C) challenge analysed by qRT-PCR. (B and C) CgIRF2 specifically activated the human IFNβ (B) and ISRE (C) promoters in a concentration-dependent manner. The activation was detected using dual luciferase reporter assays in human HEK293T cells. (D) Expression profile of CgIRF8 mRNA after poly(I:C) challenge analysed by qRT-PCR. (E and F) CgIRF8 specifically activated the human IFNβ (E) and ISRE (F) promoters in a concentration-dependent manner.

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