Table 2 GWAM and the average methylation of genomic regions between BT and AT siblings from the AMDTSS*

From: Twin birth changes DNA methylation of subsequent siblings

Genomic regions

Methylation in BT siblings† (mean ± SD)

Methylation in AT siblings† (mean ± SD)

P-value‡

GWAM

52.97 ± 0.32

52.99 ± 0.31

0.39

CpG island

22.77 ± 0.34

22.66 ± 0.39

0.33

CpG shelf

78.45 ± 0.47

78.58 ± 0.46

0.14

CpG shore

49.23 ± 0.43

49.23 ± 0.41

0.53

non-CGI region

74.28 ± 0.45

74.38 ± 0.44

0.19

Gene body

65.17 ± 0.35

65.22 ± 0.36

0.20

Promoter

30.83 ± 0.29

30.78 ± 0.28

0.81

Intergenic region

63.19 ± 0.40

63.23 ± 0.40

0.33

TSS1500

37.77 ± 0.34

37.76 ± 0.32

0.76

TSS200

19.40 ± 0.24

19.32 ± 0.27

0.21

5′UTR

34.00 ± 0.28

33.96 ± 0.28

0.89

1stExon

22.22 ± 0.28

22.12 ± 0.31

0.21

3′UTR

76.14 ± 0.40

76.25 ± 0.39

0.10

  1. *GWAM: genome-wide average methylation; BT: before twin birth; AT: after twin birth; AMDTSS: Australian Mammographic Density Twins and Sisters Study; SD: standard deviation.
  2. †Methylation is presented as the percentage of methylation, that is, beta-value × 100.
  3. ‡ P-value for compare the mean of methylation between BT and AT siblings.
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