Figure 2 | Scientific Reports

Figure 2

From: A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells

Figure 2

Functional characterization of MSC or iPSC-derived SMC TEBVs from healthy and Progeria patients. (A) Weekly outer diameter measurements of TEBVs fabricated with either MSCs, normal iSMCs, or HGPS iSMCs and seeded with hCB-ECs. (B) Weekly response to 1 μM phenylephrine of TEBVs fabricated with either MSCs, normal iSMCs, or HGPS iSMCs and seeded with hCB-ECs. (C) Weekly response to 1 μM acetylcholine of TEBVs fabricated with either MSCs, normal iSMCs, or HGPS iSMCs and seeded with hCB-ECs. Data are represented as mean ± S.E.M. n = 3 TEBVs. n.s. = not significant, ***P < 0.001, #P < 0.0001 at week 4.

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