Table 2 Mouse baseline parameters after treatment with APAP (wildtype animals) or acute CCl4 treatment (wildtype and DeltaKlf6 animals).
From: Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury
APAP (500 mg/kg) | Vehicle (n = 6) | APAP (n = 8) | ||
|---|---|---|---|---|
ALT [U/l] | 53.33 ± 3.33 | 2259 ± 458.2** | ||
AST [U/l] | 60.0 ± 7.07 | 4090 ± 720.1*** | ||
GLDH [U/l] | 10.67 ± 0.67 | 215.5 ± 42.62** | ||
Liver/bodyweight-ratio [%] | 7.63 ± 0.38 | 8.06 ± 0.53 | ||
CCl 4 (2 µl/g) | Vehicle (n = 4) | CCl 4 (n = 5) | ||
wt | Delta Klf6 | wt | Delta Klf6 | |
ALT [U/l] | 38.3 ± 8.4 | 49.2 ± 3.4 | 733.2 ± 105.7** | 704 ± 132.6** |
AST [U/l] | 12.8 ± 0.8 | 6.0 ± 1.6** | 1444 ± 198** | 1423 ± 234.5** |
Total bilirubin [mg/dl] | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.26 ± 0.04* | 0.25 ± 0.05* |
