Figure 7
Effect of iCRT3 treatment on the neutrophil infiltration in the lungs after CLP. The lung tissues from sham, vehicle and 10 mg/kg body weight iCRT3-treated mice were harvested at 20 h after CLP. The levels of (A) MIP-2, and (B) KC mRNA, in the lung tissue homogenates were determined by qPCR. The results of qPCR analysis are normalized with actin as an internal control and are expressed as fold induction compared to the sham group. (C) Lung tissues were homogenized and MPO activity was determined spectrophotometrically. Data were expressed as mean ± SEM (n = 5–8 mice per group). *P < 0.05 versus sham and # P < 0.05 versus vehicle-treated septic animals.
