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Figure 1

From: Diethylstilbestrol administration inhibits theca cell androgen and granulosa cell estrogen production in immature rat ovary

Figure 1

Effects of diethylstilbestrol (DES) and expression of estrogen receptors (ERs) in immature rat ovaries. Histology of immature ovaries before (A) or after quadruplicate DES treatment (B). Analyses of ERα (C) and ERβ (D) mRNA localization in rat ovaries by in situ hybridization. Dose-dependent effects of estradiol (E2) and DES on the transactivation of rat ERs (E,F). COS-7 cells were transfected with a 5xGAL4-E1B/Luc expression vector and an ER-encoding vector. At 24 h post-transfection, cells were incubated with or without increasing concentrations of each estrogen for 24 h. Data represent the mean ± SEM of at least four independent experiments.

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