Table 4 Head and neck cancer risk associated with ALDH2 rs671, and ADH1B rs1229984.

From: Investigating the Association between Alcohol and Risk of Head and Neck Cancer in Taiwan

 

Cases N = 782 n (%)

Controls N = 915 n (%)

OR (95% CI)a

ADH1B rs1229984

TT (*2/*2)(Fast)

405 (51.8)

484 (52.9)

Referent

CT (*1/*2)

290 (37.1)

381 (41.6)

0.91 (0.72–1.15)

CC (*1/*1)(Slow)

87 (11.1)

50 (5.5)

2.10 (1.37–3.21)

ALDH2 rs671

GG (*1/*1)(Fast)

325 (41.6)

447 (48.8)

Referent

AG (*1/*2)

403 (51.5)

386 (42.2)

1.63 (1.28–2.08)

AA (*2/*2) (Non-functional)

54 (6.9)

82 (9.0)

1.23 (0.77–1.97)

ADH1B rs1229984 +  ALDH2 rs671

Group 1: Fast ADH1B (*2/*2) + Fast ALDH2 (*1/*1)

175 (22.4)

249 (27.2)

Referent

Group 2: Fast ADH1B (*2/*2) + Slow ALDH2 (*1/*2 + *2/*2)

230 (29.4)

235 (25.7)

1.68 (1.22–2.33)

Group 3: Slow ADH1B (*1/*1 + *1/*2) + Fast ALDH2 (*1/*1)

150 (19.2)

198 (21.6)

1.09 (0.79–1.52)

Group 4: Slow ADH1B (*1/*1 + *1/*2) + Slow ALDH2 (*1/*2 + *2/*2)

227 (29.0)

233 (25.5)

1.63 (1.18–2.23)

  1. Abbreviations: CI = confidence interval; N = number; OR = odds ratio.
  2. aOR and 95% CI were calculated using unconditional logistic regression, adjusted for sex, age, education, cigarette smoking (pack-year categories), betel quid chewing (pack-year categories), and alcohol drinking (frequency).
Back to article page