Table 6 Population attributable risk percent (PAR%) associated with ever drinking alcohol regularly for head and neck cancer overall and by different sites according to the combinations of ALDH2 rs671 and ADH1B rs1229984.
From: Investigating the Association between Alcohol and Risk of Head and Neck Cancer in Taiwan
| Â | Overall | Ethanol metabolism group | |||
|---|---|---|---|---|---|
Group 1Fast ADH1B (*2/*2) + Fast ALDH2 (*1/*1) | Group 2Fast ADH1B (*2/*2) + Slow/non-functional ALDH2 (*1/*2 + *2/*2) | Group 3Slow ADH1B (*1/*1 + *1/*2) + Fast ALDH2 (*1/*1) | Group 4Slow ADH1B (*1/*1 + *1/*2) + Slow/non-functional ALDH2 (*1/*2 + *2/*2) | ||
Head and neck cancer | 21.8% | a | 21.3% | a | 47.3% |
Oral cancer | a | a | a | a | 28.1% |
Oropharyngeal cancer | 55.7% | a | 57.1% | 92.0% | 70.0% |
Hypopharyngeal cancer | 89.1% | a | 89.9% | b | b |
Laryngeal cancer | a | a | a | b | 49.0% |
