Figure 5
Effects of RU486 micro-infusion into the AVPV or ARC on progesterone induced prolongation of oestrous cycle length in PMSG-primed female rats. RU486 or vehicle (Veh) was injected via the AVPV or ARC nuclear cannulae an hour before each progesterone injection in PMSG-primed rats. Representative examples illustrating the effects of intra-AVPV micro-infusion of vehicle (Prog-Veh, A) or RU486 (Prog-RU486, B) on oestrous cycle length. (C) Intra-AVPV administration of RU486 before progesterone significantly shortened oestrous cycle length compared with vehicle controls. Representative examples illustrating the effects of intra-ARC micro-infusion of vehicle (Prog-Veh, D) or RU486 (Pro-RU486, E) on oestrous cycle length. (F) Oestrous cycle length was not significantly altered by intra-ARC RU486 infusion compared with vehicle controls. Results are presented as means ± SEM. *P < 0.05, Veh vs Prog, n = 6–7 per group.
