Figure 6
Micro-infusion of RU486 into the ARC, but not the AVPV, reversed the inhibitory effects of intraperitoneal injection of progesterone on LH pulse frequency in female rats. Representative examples illustrating the effects of intra-AVPV administration of vehicle (artificial cerebrospinal fluid/DMSO/ethylene glycol) (A) or RU486 (C) on LH pulses in progesterone treated animals. (E) LH pulse interval was not altered by intra-AVPV administration of RU486 and compared with vehicle. Representative LH profiles illustrating the effects of intra-ARC administration of vehicle (B) or RU486 (D) in progesterone treated animals. (F) Intra-ARC RU486 infusion significantly decreased LH pulse interval compared with vehicle controls. Results are presented as means ± SEM. *P < 0.05, Prog-Veh vs Prog-RU486; n = 6–7 per group. LH pulses are indicated by the asterisk (*).
