Figure 1
From: Cardiorespiratory pathogenesis of sickle cell disease in a mouse model
Decreased body size and abnormal respiratory activity in a cohort of SAD mouse pups. (A) Representative pictures of decreased body sizes in newborn SAD mice: WT (left), SAD<20 (middle, body weight of less than 20% decrease), and SAD>20 (right, body weight of more than 20% decrease). The SAD>20 appears pallor. (B) Representative plethysmographic recordings demonstrating abnormal respiratory activity in some P3 SAD mice: regular breathing patterns in WT (top) and SAD<20 (middle), irregular breathing patterns with periods of apnea in SAD>20 (bottom) mice. Population data (relative to WT): (C) respiratory variables (frequency: fR; tidal volume: VT; minute ventilation: VE); (D) Total apnea duration. *p < 0.05; **p < 0.01; one-way ANOVA followed by Holm-Sidak method for (C). *p < 0.05; Kruskal-Wallis one-way ANOVA on ranks followed by Dunn’s method for (D).
