Figure 2
From: Cardiorespiratory pathogenesis of sickle cell disease in a mouse model
Abnormal respiratory activity in SAD pups at P7-P8 under normoxic and hypoxic (8% O2) conditions. Representative plethysmographic recordings of respiratory pattern in P8 WT (A) and SAD>20 (B) mice under normoxic (top trace) and hypoxic conditions. Note the induction of apneas and seizure-like activity after 3 minutes of hypoxia (3rd trace) followed by gasping in SAD>20. Population data: (C) Total duration of apneas; (D) seizure severity grade during 5 min of 8% O2. *p < 0.05; **p < 0.01; ***p < 0.001 using two-way RM ANOVA Holm-Sidak method for (C) and one way ANOVA Holm-Sidak method for (D). (E) Survival rate after exposure to 30 min of 8% O2 using Kaplan-Meier Survival analysis (log-Rank; Holm-Sidak method; WT vs SAD<20: p < 0.01; WT vs SAD>20: p < 0.001; SAD<20 vs SAD>20: p < 0.04).
