Figure 7
From: Cardiorespiratory pathogenesis of sickle cell disease in a mouse model
Organ weights, hematocrit level and sickled cell counts in SAD mice. Organ weights were normalized to body weight in comparison to WT at P7-P8 (A) and 7–8 months (B). Hypoxia was applied with 8% O2 30 min for P7-P8, and 60 min for adult mouse. Decreased hematocrit (C) and an increased percentage of sickled cells (D) in SAD mice in room air and after 8% O2 (10 min for P7-P8; 60 min for 7–8 months old). WT had no sickled cells (n = 12 each group). *p < 0.05; **p < 0.01; ***p < 0.001 using one-way ANOVA Holm-Sidak method for A and B; two-way RM ANOVA Holm-Sidak method for (C and D).
