Figure 1 | Scientific Reports

Figure 1

From: Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20

Figure 1

The HCMV US14-22 genomic region encodes several immune evasion mechanisms. (A) FACS staining for different NK cell ligands on Human Foreskin Fibroblast cells, 96 hours after infection with WT HCMV TB40/e or HCMV TB40/e deleted for the US14-22 genomic region (or control uninfected cells, as depicted in the figure legend). Filled gray histograms represent staining with the relevant isotype control antibodies. A representative isotype control staining derived from the uninfected cells is presented as no significant differences were observed between isotype control stainings for each infection. (B) FACS staining of B7-H6 surface expression on ARPE19 cells infected with different HCMV strains as depicted in the figure legend. No significant differences were observed between isotype control stainings of each infection, so a representative isotype control staining derived from the uninfected cells is presented.

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