Figure 4 | Scientific Reports

Figure 4

From: Compulsive methamphetamine taking in the presence of punishment is associated with increased oxytocin expression in the nucleus accumbens of rats

Figure 4

PCR validation of changes in oxytocin mRNA levels in the rat NAc after a month withdrawal from methamphetamine SA and footshocks. We conducted quantitative PCR using individual RNA from the NAc (a,c) and dorsal striatum (b,d) of rats from the various conditions (CT, n = 6–8; SR, n = 6–8; SS, n = 6–9; YSR, n = 3; YSS, n = 3–6). The shock-resistant rats showed significant increases in oxytocin (a) and oxytocin receptor (c) in the NAc but not in the dorsal striatum (b and d, respectively). Values are means ± SEM fold changes relative to the control group. Key to statistics: **p < 0.01, ***p < 0.001, in comparison to the control group; ##p < 0.01, in comparison to YSR rats; ^^p < 0.01, in comparison to the YSS group; $p < 0.05, $$p < 0.01 in comparison to the SR group.

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