Table 2 The risk of metachronous colorectal neoplasia in multivariate analyses.

From: Metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia

 

Any colorectal neoplasia

Advanced colorectal neoplasia

aHRa (95% CI)

P value

aHRa (95% CI)

P value

Obesity and metabolic status

 MHNO (n = 2,745)

Reference

 

Reference

 

 MANO (n = 3,267)

1.15 (1.04–1.26)

0.005

1.43 (1.12–1.84)

0.005

 MHO (n = 707)

1.12 (0.97–1.36)

0.121

1.39 (0.95–2.03)

0.108

 MAO (n = 2,612)

1.21 (1.10–1.34)

<0.001

1.52 (1.18–1.96)

0.001

Age

1.03 (1.02–1.04)

<0.001

1.05 (1.04–1.07)

<0.001

Male sex

1.32 (1.19–1.48)

<0.001

1.45 (1.10–1.92)

0.009

Current smoking

1.31 (1.17–1.46)

<0.001

1.76 (1.34–2.30)

<0.001

Modest alcohol intake

1.12 (1.02–1.22)

0.017

1.11 (0.90–1.37)

0.333

Regular exercise

0.90 (0.84–0.98)

0.009

0.89 (0.74–1.07)

0.197

Regular aspirin use

1.05 (0.93–1.18)

0.425

1.21 (0.95–1.55)

0.13

Family history of CRC

1.10 (0.96–1.25)

0.168

1.06 (0.76–1.47)

0.753

High risk adenomab at screening colonoscopy

1.91 (1.74–2.10)

<0.001

3.03 (2.48–3.69)

<0.001

  1. aEstimated from Cox proportional hazard models adjusted for age, sex, smoking status, alcohol intake, regular exercise, regular aspirin use, family history of colorectal cancer, and high risk adenoma at screening colonoscopy.
  2. bHigh risk adenoma includes any adenoma larger than 1 cm, 3 or more adenomas, any adenoma with a villous component, or high-grade dysplasia.
  3. aHR, adjusted hazards ratio; CI, confidence interval; MHNO, metabolically healthy non-obese; MANO, metabolically abnormal non-obese; MHO, metabolically healthy obese; MAO, metabolically abnormal obese; CRC, colorectal cancer.
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