Table 2 Univariate and multivariable analysis for logistic regression of diabetic foot disease.

From: Sarcopenia is independently associated with diabetic foot disease

Parameters

Crude*

Models‡

Multivariable†

OR(95% CI)

P Value

OR(95% CI)

P Value

Age (year)

1.03(1.01,1.05)

0.007

Multivariable analysis for Sarcopenia

BMI (kg/m2)

0.92(0.87,0.98)

0.011

Model 1

2.48(1.63,3.77)

<0.001

HbA1c (%)

1.18(1.09,1.28)

<0.001

Model 2

2.49(1.14,4.41)

0.002

PAD

23.74 (11.71,48.13)

<0.001

Model 3

2.20(1.24,3.93)

0.007

DPN

1.81(1.12,2.94)

0.016

Model 4

2.15(1.21,3.83)

0.009

DR

2.53(1.71,3.73)

<0.001

Model 5

2.40(1.36,4.25)

0.003

DKD

2.01(1.22,2.98)

0.006

Model 6

2.12(2.18,3.81)

0.012

SMI

0.67(0.55, 0.81)

<0.001

Model 7

2.14(1.18,3.86)

0.012

Sarcopenia

2.77(1.84,4.18)

<0.001

Model 8

2.06(1.08,3.95)

0.029

  1. *Crude: Univariate logistic regression analyses for the association between potential risk factors and DFD. †Multivariable: Multivariable logistic regression analyses to test whether sarcopenia is independently associated with DFD. In the univariate or multivariable logistic regression analyses, DFD was used as the dependent.
  2. ‡Models were established as follows:
  3. Model 1: Adjusted for gender, age, duration of T2D, duration of DFD;
  4. Model 2: Model 1 + adjusted for BMI, smoking, hypertension, serum creatinine concentration;
  5. Model 3: Model 2 + adjusted for White Blood Cell and HbA1c;
  6. Model 4: Model 3 + adjusted for DKD;
  7. Model 5: Model 4 + adjusted for DR;
  8. Model 6: Model 5 + adjusted for DPN;
  9. Model 7: Model 6 + adjusted for PAD;
  10. Model 8: Model 7 + adjusted for medications, including metformin, insulin secretagogues, insulin, ACEI/ARB and diuretics.
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