Table 2 Characteristics of ARI patients positive for RSV in comparison to ARI patients negative for RSV.

From: Acute respiratory infections in hospitalized children in Vientiane, Lao PDR – the importance of Respiratory Syncytial Virus

Characteristics

RSV-positive n (%)

RSV-negative n (%)

OR (95% CI)

p-value

Number of patients

157 (41.0)

226 (59.0)

Demographics

 Age (months), median (IQR)

11 (4–18)

14 (6–27)

  

 Age groups

  Less than 1-month-old

10 (6.4)

4 (1.8)

reference

 

  1 to less than 3-month-old

16 (10.2)

26 (11.5)

0.2 (0.06–0.9)

0.061

 3 –month-old to less than 1-year-old

56 (35.7)

65 (28.8)

0.3 (0.1–1.1)

0.09

  1 to less than 2-year-old

56 (35.7)

63 (27.9)

0.3 (0.1–1.2)

0.09

  2 to less than 3-year-old

16 (10.2)

33 (14.6)

0.2 (0.05–0.7)

0.013

  3 to less than 4-year-old

3 (1.9)

24 (10.6)

0.05 (0.01–0.3)

<0.001

  4 to less than 5-year-old

0 (0.0)

11 (4.9)

NA

<0.001

 Gender (Male)

94 (59.9)

125 (55.3)

1.2 (0.7–1.8)

0.217

 Birth weight (g), median (IQR)

3,100 (2,700–3,400)

3,000 (2,700–3,300)

  

  Low birth weight 347¥

17 (12.1)

29 (14.0)

0.8 (0.4–1.6)

0.369

 Wards

  ICU

27 (17.2)

31 (13.7)

1.3 (0.7–2.2)

0.214

  Paediatric Infectious Disease

17 (10.8)

41 (18.1)

0.5 (0.3–1.0)

0.033

  General Paediatric

113 (72.0)

154 (68.1)

1.2 (0.7–1.8)

0.246

 Season (Wet season*)

144 (97.1)

112 (49.6)

11.2 (6.0–21.0)

<0.001

 PVC 13 received268♯

68 (57.1)

75 (50.3)

1.3 (0.8–2.0)

0.268

Clinical presentation

 Duration of illness prior to hospitalization (day), median (IQR)

4 (3–5)

3 (2–5)

  

 Fever documented at enrolment381

94 (60.6)

141 (62.4)

0.9 (0.6–1.4)

0.406

 Cough381

155 (99.4)

213 (94.7)

8.7 (1.1–67.9)

0.010

 Difficulty breathing375

134 (87.0)

141 (63.8)

3.8 (2.2–6.5)

<0.001

 Coryza380

149 (95.5)

190 (84.8)

3.8 (1.6–8.8)

0.001

 Diarrhea372

75 (48.4)

80 (36.9)

1.6 (1.1–2.4)

0.017

 Conjunctival suffusion361

1 (0.7)

11 (5.1)

0.1 (0.02–0.9)

0.016

 Convulsions378

6 (3.9)

34 (15.2)

0.2 (0.09–0.5)

<0.001

 Rigors328

6 (4.7)

28 (13.9)

0.3 (0.1–0.8)

0.005

 Vomiting374

93 (60.8)

115 (52.0)

1.4 (0.9–2.2)

0.058

Physical examination

 Chest indrawing378

115 (74.2)

101 (45.3)

3.5 (2.2–5.4)

<0.001

 Nasal flaring371

43 (28.7)

43 (19.5)

1.7 (1.02–2.7)

0.027

 Lymphadenopathy359

2 (1.3)

19 (9.0)

0.1 (0.03–0.6

0.001

 Abnormal pulmonary auscultation366

137 (91.3)

121 (56.0)

8.3 (4.4–15.5)

<0.001

 Tachypnea364

89 (58.9)

82 (38.55)

2.3 (1.5–3.5)

<0.001

 Oxygen saturation<90% in room air342

17 (11.5)

30 (15.5)

0.7 (0.4–1.3)

0.184

 Rashes366

8 (5.4)

16 (7.4)

0.7 (0.3–1.7)

0.296

 Respiratory distress367

48 (32.7)

60 (27.3)

1.3 (0.8–2.0)

0.161

 Central cyanosis372

20 (13.2)

26 (11.8)

1.1 (0.6–2.1)

0.393

 Wheeze369

51 (33.6)

62 (28.6)

1.3 (0.8–1.9)

0.182

 Stridor365

3 (2.0)

13 (6.0)

0.3 (0.09–1.1)

0.053

 Grunting369

5 (3.4)

13 (5.9)

0.6 (0.2–1.6)

0.193

 Inability to drink368

17 (11.3)

28 (12.9)

0.9 (0.5–1.6)

0.380

 Prostration or lethargy368

9 (6.0)

18 (8.3)

0.7 (0.3–1.6)

0.263

Outcomes

 Pneumonia

132 (84.1)

145 (64.2)

2.9 (1.8–4.9)

<0.001

 Severe pneumonia

46 (29.3)

92 (40.7)

0.6 (0.4–0.9)

0.014

 Length of stay ≤ 5 days 376

132 (85.2)

173 (78.3)

1.6 (0.9–2.8)

0.060

 Supplementary oxygen used378

29 (18.7)

40 (17.9)

1.1 (0.6–1.8)

0.476

 Death

2 (1.3)

3 (1.4)

0.9 (0.2–5.8)

0.666

Detection of:

 S. pneumoniae

98 (62.4)

115 (50.9)

1.6 (1.1–2.4)

0.016

 H. influenzae

84 (53.5)

120 (53.1)

1.0 (0.7–1.5)

0.510

 Influenzavirus

1 (0.6)

28 (12.4)

0.05 (0.01–0.3)

<0.001

 Human parainfluenza virus

3 (1.9)

34 (15.0)

0.1 (0.03–0.4)

<0.001

 Human metapneumovirus

0 (0.0)

6 (2.7)

NA

0.041

 Human adenovirus

6 (3.8)

22 (9.7)

0.4 (0.1–0.9)

0.021

 Human rhinovirus

12 (7.6)

58 (25.7)

0.2 (0.1–0.5)

<0.001

  1. Data in the table are number of patients and percentages, except for a few variables for which the unit is specified.
  2. Because of missing values, superscript numbers indicate the number of patients for whom data were available.
  3. Low birth weight: defined by World Health Organisation as weight at birth less than 2,500 g31.
  4. Fever: defined as body temperature ≥38 °C per axilla32.
  5. Children less than 2 years old were defined as ‘PCV13 received’ if they had received: at least two doses of vaccine for children less than 1 year old or at least one dose of vaccine for children between 1 to 2 years old.
  6. Wet season: from May to October.